Samuel married Mary Million 15 Feb 1821. Mary (daughter of John Million and Sarah Boothe) was born 27 Mar 1799, Washington, Tennessee, USA; died 24 Feb 1863, Washington, Tennessee, USA. [Group Sheet]

1. Casamore Ephraim May was born 6 May 1823; died 3 Jul 1897, Knoxville, Knox, Tennessee, USA.
2. David May was born 19 Jul 1826; died 19 Sep 1826.
3. Edward J. May was born 24 Mar 1829; died 19 Sep 1829.
4. Eliza May was born 4 Jan 1825; died 14 Jun 1889.
5. George W. May was born 23 Aug 1827.
6. James G. May was born 9 Dec 1835.
7. John A. May was born 21 Feb 1822.
8. Martin May was born 30 Oct 1834; died 15 Feb 1835.
9. Mary Ann May was born 6 Jan 1833.
10. Priscilla May was born 2 Apr 1831; died 19 May 1833.
11. Samuel Francis May was born 3 May 1840.
12. William May was born 14 Sep 1837.