William married Elizabeth Straley. Elizabeth (daughter of Jacob Straley and Susan Barbor) was born 1762, Lynchburg, Campbell, Virginia, USA; died , Botetourt, Virginia, USA. [Group Sheet]

1. Alexander Caldwell was born 1757, Knox, Tennessee, USA; died 1830, Knox, Tennessee, USA.
2. Alexander Caldwell was born 27 Jun 1829.
3. Chester Caldwell was born 24 Jun 1826.
4. Eleanor Caldwell was born 27 Oct 1812.
5. Fleming Caldwell was born 29 Aug 1818.
6. James Caldwell was born 29 Jan 1834.
7. John Caldwell was born 10 Feb 1811.
8. Margaret Caldwell was born 9 Sep 1820.
9. Nancy Caldwell was born 24 Nov 1814.
10. Sarah Caldwell was born 20 Nov 1816.
11. Thomas Caldwell was born 19 Jul 1822.
12. William Caldwell was born 1771, Tennessee, USA; died 4 Feb 1849, Botetourt, Virginia, USA.
13. Joseph Caldwell
14. Robert Caldwell
15. Walter Caldwell